Expression of deubiquitinating enzyme genes in the developing mammal retina.

ABSTRACT: Purpose:Genes involved in the development and differentiation of the mammalian retina are also associated with inherited retinal dystrophies (IRDs) and age-related macular degeneration. Transcriptional regulation of retinal cell differentiation has been addressed by genetic and transcriptomic studies. Much less is known about the posttranslational regulation of key regulatory proteins, although mutations in some genes involved in ubiquitination and proteostasis-E3 ligases and deubiquitinating enzymes (DUBs)-cause IRDs. This study intends to provide new data on DUB gene expression during different developmental stages of mouse and human fetal retinas. Methods:We performed a comprehensive transcriptomic analysis of all the annotated human and mouse DUBs (87) in the developing mouse retina at

SUBMITTER: Esquerdo-Barragan M 

PROVIDER: S-EPMC6887694 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature