Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid.

ABSTRACT: Background:Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off-label. Surgeons lack guidelines regarding safe topical dosages and modes of administration. The effects of topical TXA on skin cells and wound healing are unknown. This study investigated whether topical TXA might be cytotoxic or affect wound re-epithelialization. Methods:Human keratinocytes and fibroblast cell cultures and an ex vivo human skin wound model were subjected to both short (limited) and long (chronic) exposure to various clinically relevant concentrations of TXA to mimic different modalities of topical administration. Cytotoxicity and effects on wound re-epithelia

SUBMITTER: Eikebrokk TA 

PROVIDER: S-EPMC6887721 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature