Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants.

ABSTRACT:

Background

Infant gut dysbiosis, often associated with low abundance of bifidobacteria, is linked to impaired immune development and inflammation-a risk factor for increased incidence of several childhood diseases. We investigated the impact of B. infantis EVC001 colonization on enteric inflammation in a subset of exclusively breastfed term infants from a larger clinical study.

Methods

Stool samples (n = 120) were collected from infants randomly selected to receive either 1.8 × 10¹⁰ CFU B. infantis EVC001 daily for 21 days (EVC001) or breast milk alone (controls), starting at day 7 postnatal. The fecal microbiome was analyzed using 16S ribosomal RNA, proinflammatory cytokines using multiplexed immunoassay, and fecal calprotectin using ELISA at three time points: d

SUBMITTER: Henrick BM 

PROVIDER: S-EPMC6887859 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature