Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review.

ABSTRACT: Particulate matter (PM) exposure is associated with the development of cardiopulmonary disease. Our group has studied the adverse health effects of World Trade Center particulate matter (WTC-PM) exposure on firefighters. To fully understand the complex interplay between exposure, organism, and resultant disease phenotype, it is vital to analyze the underlying role of genomics in mediating this relationship. A PubMed search was performed focused on environmental exposure, genomics, and cardiopulmonary disease. We included original research published within 10 years, on epigenetic modifications and specific genetic or allelic variants. The initial search resulted in 95 studies. We excluded manuscripts that focused on work-related chemicals, heavy metals and tobacco smoke as primary sources o

SUBMITTER: Citron J 

PROVIDER: S-EPMC6887978 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature