Neonatal Diet Impacts Bioregional Microbiota Composition in Piglets Fed Human Breast Milk or Infant Formula.

ABSTRACT:

Background

Early infant diet influences postnatal gut microbial development, which in turn can modulate the developing immune system.

Objectives

The aim of this study was to characterize diet-specific bioregional microbiota differences in piglets fed either human breast milk (HM) or infant formula.

Methods

Male piglets (White Dutch Landrace Duroc) were raised on HM or cow milk formula (MF) from postnatal day (PND) 2 to PND 21 and weaned to an ad libitum diet until PND 51. Piglets were euthanized on either PND 21 or PND 51, and the gastrointestinal contents were collected for 16s RNA sequencing. Data were analyzed using the Quantitative Insight into Microbial Ecology. Diversity measurements (Chao1 and Shannon) and the Wald test were used to determine relative abundance

SUBMITTER: Brink LR 

PROVIDER: S-EPMC6888031 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature