Effects of erythropoietin on fibroblast growth factor 23 in mice and humans.

ABSTRACT:

Background

Erythropoietin (EPO) has been reported as a novel determinant of fibroblast growth factor 23 (FGF23) production; however, it is unknown whether FGF23 is stimulated by chronic exposure to EPO or by EPO administration in nonpolycystic chronic kidney disease (CKD) models.

Methods

We analyzed the effects of chronic EPO on FGF23 in murine models with chronically high EPO levels and normal kidney function. We studied the effects of exogenous EPO on FGF23 in wild-type mice, with and without CKD, injected with EPO. Also, in four independent human CKD cohorts, we evaluated associations between FGF23 and serum EPO levels or exogenous EPO dose.

Results

Mice with high endogenous EPO have elevated circulating total FGF23, increased disproportionately to intact FGF23, su

SUBMITTER: Hanudel MR 

PROVIDER: S-EPMC6888066 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature