Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?

ABSTRACT: Heat shock proteins (HSPs) are evolutionary conserved proteins that work as molecular chaperones and perform broad and crucial roles in proteostasis, an important process to preserve the integrity of proteins in different cell types, in health and disease. Their function in cancer is an important aspect to be considered for a better understanding of disease development and progression. Glioblastoma (GBM) is the most frequent and lethal brain cancer, with no effective therapies. In recent years, HSPs have been considered as possible targets for GBM therapy due their importance in different mechanisms that govern GBM malignance. In this review, we address current evidence on the role of several HSPs in the biology of GBMs, and how these molecules have been considered in different treatments

SUBMITTER: Iglesia RP 

PROVIDER: S-EPMC6888131 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature