Respiratory Sinus Arrhythmia Attenuation via Targeted Lung Denervation in Sheep and Humans.

ABSTRACT:

Background

Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung. Parasympathetic input to the heart originating from the lungs contributes to respiratory sinus arrhythmia (RSA) and disruption of pulmonary nerves via TLD may impact RSA.

Objective

The aim of this study was to assess the potential of TLD to affect RSA in sheep and humans.

Methods

TLD was performed in 5 sheep and 9 humans using a novel lung denervation system (Nu-vaira Inc., Minneapolis, MN, USA) with an electrocardiogram collected before and after the procedure. Frequency domain analysis of heart rate variability was performed in 5 sheep and 6 humans with presence of RSA approximated as high-frequency power (HF power).

Results

SUBMITTER: Valipour A 

PROVIDER: S-EPMC6888888 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature