Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity.

ABSTRACT:

Background

There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little is known about the impact of obesity on epigenetic aging of metabolically active visceral adipose tissue (VAT). Herein, we aimed to test whether obesity accelerates VAT epigenetic aging in subjects with severe obesity.

Results

A significant and positive correlation between chronological age and epigenetic age, estimated with a reduced version of the Horvath's epigenetic clock, was found in both blood (r = 0.78, p = 9.4 × 10^-12) and VAT (r = 0.80, p = 1.1 × 10^-12). Epigenetic age acceleration, defined as the residual resulting from regressing epigenetic age on chronological age,

SUBMITTER: de Toro-Martin J 

PROVIDER: S-EPMC6888904 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature