MiR-1/206 downregulates splicing factor Srsf9 to promote C2C12 differentiation.

ABSTRACT:

Background

Myogenesis is driven by specific changes in the transcriptome that occur during the different stages of muscle differentiation. In addition to controlled transcriptional transitions, several other post-transcriptional mechanisms direct muscle differentiation. Both alternative splicing and miRNA activity regulate gene expression and production of specialized protein isoforms. Importantly, disruption of either process often results in severe phenotypes as reported for several muscle diseases. Thus, broadening our understanding of the post-transcriptional pathways that operate in muscles will lay the foundation for future therapeutic interventions.

Methods

We employed bioinformatics analysis in concert with the well-established C2C12 cell system for predicting and va

SUBMITTER: Bjorkman KK 

PROVIDER: S-EPMC6888935 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature