Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures.

ABSTRACT:

Background

Adolescence is a period characterized by major biological development, which may be associated with changes in DNA methylation (DNA-M). However, it is unknown to what extent DNA-M varies from pre- to post-adolescence, whether the pattern of changes is different between females and males, and how adolescence-related factors are associated with changes in DNA-M.

Methods

Genome-scale DNA-M at ages 10 and 18 years in whole blood of 325 subjects (n = 140 females) in the Isle of Wight (IOW) birth cohort was analyzed using Illumina Infinium arrays (450K and EPIC). Linear mixed models were used to examine DNA-M changes between pre- and post-adolescence and whether the changes were gender-specific. Adolescence-related factors and environmental exposure factors were assesse

SUBMITTER: Han L 

PROVIDER: S-EPMC6888960 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature