Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis.

ABSTRACT:

Background

Vitamin D deficiency, determined by blood levels of 25-hydroxyvitamin D [25(OH) D, i.e. the major vitamin D form in blood], has been shown to associate with all-cause mortalities. We recently demonstrated that blood levels of 1,25-dihydroxyvitamin D [1,25(OH)₂D, i.e. the active vitamin D] were significantly lower in non-survivors compared to survivors among sepsis patients. Unexpectedly, despite the well documented roles of 1,25(OH)₂D in multiple biological functions such as regulation of immune responses, stimulation of antimicrobials, and maintenance of barrier function, 1,25(OH)₂D supplementation failed to improve disease outcomes. These previous findings suggest that, in addition to 1,25(OH)₂D deficiency, disorders leading

SUBMITTER: Li CH 

PROVIDER: S-EPMC6888965 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature