Evidence for Dissociable Linkage of Dimensions of Psychopathology to Brain Structure in Youths.

ABSTRACT:

Objective

High comorbidity among psychiatric disorders suggests that they may share underlying neurobiological deficits. Abnormalities in cortical thickness and volume have been demonstrated in clinical samples of adults, but less is known when these structural differences emerge in youths. The purpose of this study was to examine the association between dimensions of psychopathology and brain structure.

Methods

The authors studied 1,394 youths who underwent brain imaging as part of the Philadelphia Neurodevelopmental Cohort. Dimensions of psychopathology were constructed using a bifactor model of symptoms. Cortical thickness and volume were quantified using high-resolution 3-T MRI. Structural covariance networks were derived using nonnegative matrix factorization and analyz

SUBMITTER: Kaczkurkin AN 

PROVIDER: S-EPMC6888993 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature