Evaluation of Diffusion-Weighted MRI and FDG-PET/CT to Assess Response to AdCD40L treatment in Metastatic Melanoma Patients.

ABSTRACT: The purpose was to evaluate the potential of diffusion-weighted-magnetic resonance imaging (DW-MRI) and ¹⁸F-fludeoxy-glucose-positron emission tomography integrated with CT (FDG-PET/CT) for prediction of overall survival (OS) following AdCD40L-immunotherapy in patients with metastatic malignant melanoma (MMM). Twenty-four patients with refractory MMM were treated with immunostimulatory AdCD40L gene therapy in a phase I/IIa study. Pre-therapeutic DW-MRI and FDG-PET/CT were performed and then repeated at 5 and 9 weeks post-treatment. Evaluation was conducted according to RECIST 1.1 and EORTC criteria. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), maximum standardized uptake value (SUV_max) were measured in the injected lesions. Fold changes (F) in

SUBMITTER: Schiza A 

PROVIDER: S-EPMC6889008 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature