Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons.

ABSTRACT:

Background

Transcranial magnetic stimulation (TMS) enables non-invasive modulation of brain activity with both clinical and research applications, but fundamental questions remain about the neural types and elements TMS activates and how stimulation parameters affect the neural response.

Objective

To develop a multi-scale computational model to quantify the effect of TMS parameters on the direct response of individual neurons.

Methods

We integrated morphologically-realistic neuronal models with TMS-induced electric fields computed in a finite element model of a human head to quantify the cortical response to TMS with several combinations of pulse waveforms and current directions.

Results

TMS activated with lowest intensity intracortical axonal terminations in t

SUBMITTER: Aberra AS 

PROVIDER: S-EPMC6889021 | biostudies-literature | 2020 Jan - Feb

REPOSITORIES: biostudies-literature