Prognostic Potential of Alternative Splicing Markers in Endometrial Cancer.

ABSTRACT: Alternative splicing (AS), an important post-transcriptional regulatory mechanism that regulates the translation of mRNA isoforms and generates protein diversity, has been widely demonstrated to be associated with oncogenic processes. In this study, we systematically analyzed genome-wide AS patterns to explore the prognostic implications of AS in endometrial cancer (EC). A total of 2,324 AS events were identified as being associated with the overall survival of EC patients, and eleven of these events were further selected using a random forest algorithm. With the implementation of a generalized, boosted regression model, a prognostic AS model that aggregated these eleven markers was ultimately established with high performance for risk stratification in EC patients. Functional analysis of

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6889075 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature