Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers.

ABSTRACT:

Background

Cannabis proofed to be effective in pain relief, but one major side effect is its influence on memory in humans. Therefore, the role of memory on central processing of nociceptive information was investigated in healthy volunteers.

Methods

In a placebo-controlled cross-over study including 22 healthy subjects, the effect of 20 mg oral Δ⁹-tetrahydrocannabinol (THC) on memory involving nociceptive sensations was studied, using a delayed stimulus discrimination task (DSDT). To control for nociceptive specificity, a similar DSDT-based study was performed in a subgroup of thirteen subjects, using visual stimuli.

Results

For each nociceptive stimulus pair, the second stimulus was associated with stronger and more extended brain activations than the fir

SUBMITTER: Walter C 

PROVIDER: S-EPMC6889084 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature