Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambui-Epigen Cohort Study of Aging.

ABSTRACT: Age-related cognitive decline (ACD) is the gradual process of decreasing of cognitive function over age. Most genetic risk factors for ACD have been identified in European populations and there are no reports in admixed Latin American individuals. We performed admixture mapping, genome-wide association analysis (GWAS), and fine-mapping to examine genetic factors associated with 15-year cognitive trajectory in 1,407 Brazilian older adults, comprising 14,956 Mini-Mental State Examination measures. Participants were enrolled as part of the Bambuí-Epigen Cohort Study of Aging. Our admixture mapping analysis identified a genomic region (3p24.2) in which increased Native American ancestry was significantly associated with faster ACD. Fine-mapping of this region identified a single nucleotide pol

SUBMITTER: Gouveia MH 

PROVIDER: S-EPMC6889148 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature