Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix.

ABSTRACT:

Background

The extracellular matrix (ECM) is essential for malignant tumour progression, as it is a physical barrier to various kinds of anticancer therapies. Matrix metalloproteinase (MMPs) can degrade almost all ECM components, and macrophages are an important source of MMPs. Studies using macrophages to treat tumours have shown that macrophages can enter tumour tissue to play a regulatory role.

Methods

We modified macrophages with a designed chimeric antigen receptor (CAR), which could be activated after recognition of the tumour antigen HER2 to trigger the internal signalling of CD147 and increase the expression of MMPs.

Results

Although CAR-147 macrophage treatment did not affect tumour cell growth in vitro compared with control treatment. However, we found that

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6889154 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature