Effect of tetracycline treatment regimens on antibiotic resistance gene selection over time in nursery pigs.

ABSTRACT:

Background

The majority of antimicrobials given during the production of pigs are given to nursery pigs. The influence of antimicrobial use on the levels of antimicrobial resistant (AMR) genes is important to quantify to be able to assess the impact of resistance on the food chain and risk to human and animal health.

Results

This study investigated the response on the levels of nine AMR genes to five different treatment strategies with oxytetracycline, and the dynamics of gene abundance over time by following 1167 pigs from five different farms in Denmark. The results showed no significant difference between treatments and an increase in abundance for the efflux pump encoding tet(A) gene and the genes encoding the ribosomal protection proteins tet(O) and tet(W) tetracycline

SUBMITTER: Græsboll K 

PROVIDER: S-EPMC6889206 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature