Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups.

ABSTRACT:

Background

Toll-like receptors (TLRs) are the most widely studied innate immunity receptors responsible for recognition of invading pathogens. Among the TLR family, TLR5 is the only that senses and recognizes flagellin, the major protein of bacterial flagella. TLR5 has been reported to be under overall purifying selection in mammals, with a small proportion of codons under positive selection. However, the variation of substitution rates among major mammalian groups has been neglected. Here, we studied the evolution of TLR5 in mammals, comparing the substitution rates among groups.

Results

In this study we analysed the TLR5 substitution rates in Euungulata, Carnivora, Chiroptera, Primata, Rodentia and Lagomorpha, groups. For that, Tajima's relative rate test, Bayesian inferen

SUBMITTER: Pinheiro A 

PROVIDER: S-EPMC6889247 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature