Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development.

ABSTRACT: Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements. Previous studies indicated that spatial and temporal patterns of gene expression in the gastrula predispose individual regions to distinct cell fates. However, the underlying epigenetic mechanisms remain largely unexplored. Here, we profile the spatiotemporal landscape of the epigenome and transcriptome of the mouse gastrula. We reveal the asynchronous dynamics of proximal chromatin states during germ layer formation as well as unique gastrula-specific epigenomic features of regulatory elements, which have strong usage turnover dynamics and clear germ layer-specific signatures. Impo

SUBMITTER: Yang X 

PROVIDER: S-EPMC6889293 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature