Differential improvement of negative-symptom subfactors after cognitive remediation in low-functioning individuals with schizophrenia.

ABSTRACT:

Background

Negative symptoms and cognitive deficits have a substantial predictive value for functional deficits and recovery in schizophrenia. However, the relationship between negative symptoms and cognitive abnormalities is unclear possibly due to the heterogeneity of negative symptoms. This study used the model of expressive and experiential negative symptoms subfactors to decrease this heterogeneity. It examined these subfactors and cognition before and after treatment with computerized cognitive remediation training (CRT) in chronically-hospitalized individuals with psychosis and predominant negative symptoms.

Methods

Seventy-eight adult participants with a DSM-IV-TR diagnosis of schizophrenia or schizoaffective disorder were enrolled in a 12-week CRT program. Assessmen

SUBMITTER: Sevy S 

PROVIDER: S-EPMC6889361 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature