Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial.

ABSTRACT:

Background

We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.

Methods

We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.

Results

Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P-_trend = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P-_trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P-_trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6889387 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature