A panel of DNA methylated markers predicts metastasis of pN₀M₀ gastric carcinoma: a prospective cohort study.

ABSTRACT:

Background

The aim of this prospective study was to evaluate the feasibility of predicting GC metastasis using CDH1, GFRA1, P16 and ZNF382 DNA methylation as biomarkers.

Methods

198 GC patients without metastasis at the time of surgery resection were recruited into the double-blind cohort (NCT02159339). Gene methylation was analysed using MethyLight assays. GC metastasis and survival data were obtained from 178 patients with 94.7% compliance during follow-up.

Results

Twenty six cases of metastasis and 5 cases of recurrence were observed in 178 cases (17.4%) during the follow-up (median, 62.7 months). The GC metastasis rate for GFRA1 methylation-positive patients was significantly reduced compared with GFRA1 methylation-negative patients (odds ratio [OR]: 0.23, 95% con

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6889426 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature