Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio).

ABSTRACT:

Background

Compensatory growth refers to the phenomenon in which organisms grow faster after the improvement of an adverse environment and is thought to be an adaptive evolution to cope with the alleviation of the hostile environment. Many fish have the capacity for compensatory growth, but the underlying cellular mechanisms remain unclear. In the present study, microarray and nontargeted metabolomics were performed to characterize the transcriptome and metabolome of zebrafish liver during compensatory growth.

Results

Zebrafish could regain the weight they lost during 3 weeks of fasting and reach a final weight similar to that of fish fed ad libitum when refed for 15 days. When refeeding for 3 days, the liver displayed hyperplasia accompanied with decreased triglyceride cont

SUBMITTER: Jia J 

PROVIDER: S-EPMC6889435 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature