Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case-control study.

ABSTRACT:

Background

The antihypertensive agent hydrochlorothiazide has been associated with increased risks of non-melanoma skin cancer (NMSC) and possibly some melanoma subtypes. Previous studies were, however, conducted in predominantly Caucasian populations. We therefore examined the association between hydrochlorothiazide and skin cancer risk in an Asian population.

Methods

By using Taiwan's National Health Insurance Research Database (NHIRD), we conducted three separate case-control studies of lip cancer, non-lip non-melanoma skin cancer and melanoma. Cases (n = 29,082) with a first-ever skin cancer diagnoses (2008-2015) were matched 1:10 to population controls. We estimated odds ratios (ORs) associating hydrochlorothiazide use with skin cancer risk by using conditional logistic

SUBMITTER: Pottegard A 

PROVIDER: S-EPMC6889460 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature