IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.

ABSTRACT:

Background

Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and disease is ill-defined. Müller cell gliosis is a critical response during the acute phase of retinal detachment (RD), and in this study, we investigated if IL-33 was modulatory in the inflammatory and neurodegenerative pathology which is characteristic of this important clinical condition.

Methods

RD was induced by subretinal injection of sodium hyaluronate into C57BL/6 J (WT) and IL-33^-/- mice and confirmed by fundus imaging and optical coherence tomography (OCT). The expression of inflammatory cytokines, complement components and growth factors

SUBMITTER: Augustine J 

PROVIDER: S-EPMC6889479 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature