ALW peptide ameliorates lupus nephritis in MRL/lpr mice.

ABSTRACT:

Background

Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there are various therapies for patients with LN; however, most of them are associated with considerable side effects. We confirmed previously that ALW (ALWPPNLHAWVP), a 12-amino acid peptide, inhibited the binding of polyclonal anti-dsDNA antibodies to mesangial cells and isolated glomeruli in vitro. In this study, we further investigate whether the administration of ALW peptide decreases renal IgG deposition and relevant damage in MRL/lpr lupus-prone mice.

Methods

Forty female MRL/lpr mice were randomly divided into four groups. The mice were intravenously inject

SUBMITTER: Wang H 

PROVIDER: S-EPMC6889545 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature