The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

ABSTRACT:

Objectives

Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by obesity and cold exposure. It was proposed that TSK controls sympathetic innervation and thermogenesis in brown adipose tissue (BAT) and that loss of TSK protects against diet-induced obesity and improves glucose homeostasis. Here we report the impact of deleting and/or overexpressing TSK on BAT thermogenic capacity, body weight regulation, and glucose homeostasis.

Methods

We measured the expression of thermogenic genes and markers of BAT innervation and activation in TSK-null and TSK-overexpressing mice. Body weight, body tempe

SUBMITTER: Mouchiroud M 

PROVIDER: S-EPMC6889588 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature