The role of pulmonary mesenchymal cells in airway epithelium regeneration during injury repair.

ABSTRACT:

Background

The airways of mammalian lung are lined with highly specialized cell types that are the target of airborne toxicants and injury. Several epithelial cell types and bone marrow-derived mesenchymal stem cells have been identified to serve as stem cells during injury repair. However, the contributions of endogenous mesenchymal cells to recruitment, expansion or differentiation of stem cells, and repair and reestablishment of the normal composition of airway epithelium following injury have not been addressed.

Methods

The role of mouse pulmonary mesenchymal cells was investigated by lineage tracing using Dermo1-Cre; ROSA^mTmG mice. In experimental models of lung injury by lipopolysaccharide and naphthalene, GFP-labeled Dermo1⁺ mesenchymal cells wer

SUBMITTER: Fang S 

PROVIDER: S-EPMC6889622 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature