Identification of key pathways and genes in PTEN mutation prostate cancer by bioinformatics analysis.

ABSTRACT:

Background

Prostate cancer (Pca) remains one of the leading adult malignancies. PTEN (Phosphatase and Tensin Homolog) mutant is the top common mutated genes in prostate cancer, which makes it a promising biomarker in future individualized treatment.

Methods

We obtained gene expression data of prostate cancer from TCGA (The Cancer Genome Atlas) database for analysis. We analyzed the DEGs (differentially expressed genes), and used online tools or software to analyze Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene set enrichment analysis (GSEA), Search Tool for the Retrieval of Interacting Genes/Proteins, and Molecular Complex Detection.

Results

Latest TCGA data showed PTEN mutation in about 22% patients. 1736 DEGs in total were identified

SUBMITTER: Sun J 

PROVIDER: S-EPMC6889628 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature