Amplified intracellular Ca²⁺ for synergistic anti-tumor therapy of microwave ablation and chemotherapy.

ABSTRACT:

Background

Developing new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of complications. We find that mild MW irradiation can significantly increase intracellular Ca²⁺ concentration in the presence of doxorubicin hydrochloride (DOX) and thus induce massive tumor cell apoptosis. Herein, we designed a synergistic nanoplatform that not only amplifies the intracellular Ca²⁺ concentration and induce cell death under mild MW irradiation but also avoids the side effect of thermal ablation and chemotherapy.

Results

The as-made NaCl-DOX@PLGA nanoplatform selectively elevates the temperature of tumor tissue distributed

SUBMITTER: Dou JP 

PROVIDER: S-EPMC6889637 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature