A longitudinal fixel-based analysis of white matter alterations in patients with Parkinson's disease.

ABSTRACT:

Introduction

Disruption to white matter pathways is an important contributor to the pathogenesis of Parkinson's disease. Fixel-based analysis has recently emerged as a useful fiber-specific tool for examining white matter structure. In this longitudinal study, we used Fixel-based analysis to investigate white matter changes occurring over time in patients with Parkinson's disease.

Methods

Fifty patients with idiopathic Parkinson's disease (27 men and 23 women; mean age: 61.8 ± 6.1 years), were enrolled. Diffusion-weighted imaging and clinical examinations were performed at three different time points (baseline, first follow-up [after a mean of 24±2 months], and second follow-up [after a mean of 40 ± 3 months]). Additional 76 healthy control subjects (38 men and 38 women; mea

SUBMITTER: Rau YA 

PROVIDER: S-EPMC6889638 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature