Biological treatment of pediatric sarcomas by combined virotherapy and NK cell therapy.

ABSTRACT:

Background

In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to high-grade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy was found to be efficient in many pediatric sarcoma types. Also NK cell therapy was denoted to represent a promising upcoming strategy for pediatric sarcoma patients. We here investigated a combinatorial approach employing oncolytic measles vaccine virotherapeutics (MeV) together with activated human NK cells (or PBMCs).

Methods

The human sarcoma cell lines A673 and HT1080 were used to evaluate the efficacy of this combinatorial treatment modality. Oncolysis was determined by measuring real-time cell proliferation using the xCELLigence RTCA SP system. Further

SUBMITTER: Klose C 

PROVIDER: S-EPMC6889644 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature