Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model.

ABSTRACT:

Background

Diabetic nephropathy (DN) is one of the most severe chronic diabetic complications and the main cause of end-stage renal disease. Chronic inflammation plays a key role in the development of DN. However, few treatment strategies are available; therefore, new and effective strategies to ameliorate DN at the early stage must be identified.

Methods

Mesenchymal stem cells (MSCs) are characterized by anti-inflammatory and immune regulatory abilities. We developed a rhesus macaque model of DN and administered MSCs four times over 2 months. We measured blood glucose level, HbA1c, and levels of renal function parameters in the blood and urine, and cytokine levels in the kidney and blood circulatory system of rhesus macaques. Also, we analyzed the renal pathological changes

SUBMITTER: An X 

PROVIDER: S-EPMC6889652 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature