Microstructural abnormalities in deep and superficial white matter in youths with mild traumatic brain injury.

ABSTRACT:

Background

Diffusion Tensor Imaging (DTI) studies of traumatic brain injury (TBI) have focused on alterations in microstructural features of deep white matter fibers (DWM), though post-mortem studies have demonstrated that injured axons are often observed at the gray-white matter interface where superficial white matter fibers (SWM) mediate local connectivity.

Objectives

To examine microstructural alterations in SWM and DWM in youths with a history of mild TBI and examine the relationship between white matter alterations and attention.

Methods

Using DTIDWM fractional anisotropy (FA) and SWM FA in youths with mild TBI (TBI, n=63) were compared to typically developing and psychopathology matched control groups (n=63 each). Following tract-based spatial statistics, SWM F

SUBMITTER: Stojanovski S 

PROVIDER: S-EPMC6889799 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature