Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B^-/- Mice.

ABSTRACT: The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B^-/-) result in the accelerated maturation of corticostriatal circuits during the second and third postnatal weeks. Here, we show that during this period, there is extensive remodeling of the striatal synaptic proteome and a developmental switch in glutamatergic synaptic plasticity induced by cortical hyperactivity in striatal spiny projection neurons (SPNs). Behavioral abnormalities in Shank3B^-/- mice emerge during this stage and are ameliorated by normalizing excitatory synapse connectivity in medial striatal regions by the downregulation of PKA activity. The

SUBMITTER: Peixoto RT 

PROVIDER: S-EPMC6889826 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature