Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.

ABSTRACT: Chronic airway inflammation from recurring exposures to noxious environmental stimuli results in a progressive and irreversible airflow limitation and the lung parenchymal damage that characterizes chronic obstructive pulmonary disease (COPD). The large variability observed in the onset and progression of COPD is primarily driven by complex gene-environment interactions. The transcriptomic and epigenetic memory potential of lung epithelial and innate immune cells drive responses, such as mucus hyperreactivity and airway remodeling, that are tightly regulated by various molecular mechanisms, for which several candidate susceptibility genes have been described. However, the recently described noncoding RNA species, in particular the long noncoding RNAs, may also have an important role in mod

SUBMITTER: Devadoss D 

PROVIDER: S-EPMC6890411 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature