CD4⁺ CADM1⁺ cell percentage predicts disease progression in HTLV-1 carriers and indolent adult T-cell leukemia/lymphoma.

ABSTRACT: We recently took advantage of the universal expression of cell adhesion molecule 1 (CADM1) by CD4⁺ cells infected with HTLV-1 and the downregulation of CD7 expression that corresponds with the oncogenic stage of HTLV-1-infected cells to develop a flow cytometric system using CADM1 versus CD7 plotting of CD4⁺ cells. We risk-stratified HTLV-1 asymptomatic carriers (AC) and indolent adult T-cell leukemia/lymphoma (ATL) cases based on the CADM1⁺ percentage, in which HTLV-1-infected clones are efficiently enriched. AC and indolent ATL cases were initially classified according to their CADM1⁺ cell percentage. Follow-up clinical and flow cytometric data were obtained for 71 cases. In G1 (CADM1⁺ ≤ 10%) and G2 (10% < CADM1⁺ ≤ 25%) ca

SUBMITTER: Makiyama J 

PROVIDER: S-EPMC6890436 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature