Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer.

ABSTRACT: Abnormal function of human body enzymes and epigenetic alterations such as DNA methylation have been shown to lead to human carcinogenesis. Lysyl oxidase (LOX) enzyme has attracted attention due to its involvement in tumor progression in various cancers. The purpose of this study was to clarify the clinical importance of LOX expression and its epigenetic regulation in the pathogenesis of esophageal squamous cell carcinoma (ESCC). Using a database of 284 ESCCs, we examined LOX expression and its prognostic characteristics. The functional role of LOX was assessed by in vitro growth, migration, and invasion assays. The relationship between LOX expression, global DNA hypomethylation (ie, LINE-1 methylation), and LOX promoter methylation was evaluated by using mRNA expression arrays and pyroseq

SUBMITTER: Kalikawe R 

PROVIDER: S-EPMC6890447 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature