Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia.

ABSTRACT: Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the population-level effects frequently result in over or under-dosing. Here, we interrogate the relationship between population-based and individual-based responses to anesthetics in mice and zebrafish. The anesthetic state was assessed by quantifying responses to simple stimuli. Individual responses dynamically fluctuated at a fixed drug concentration. These fluctuations exhibited resistance to state transitions. Drug sensitivity varied dramatically across individuals in both species. The amount of noise driving transitions between states, in contrast, was highly conserved in vertebrates separated by 400 million years of evolution. Indiv

SUBMITTER: McKinstry-Wu AR 

PROVIDER: S-EPMC6890463 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature