Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England.

ABSTRACT:

Objective

Although U.K. and international guidelines recommend monotherapy, antipsychotic polypharmacy among patients with serious mental illness is common in clinical practice. However, empirical evidence on its effectiveness is scarce. Therefore, the authors estimated the effectiveness of antipsychotic polypharmacy relative to monotherapy in terms of health care utilization and mortality.

Methods

Primary care data from Clinical Practice Research Datalink, hospital data from Hospital Episode Statistics, and mortality data from the Office of National Statistics were linked to compile a cohort of patients with serious mental illness in England from 2000 to 2014. The antipsychotic prescribing profile of 17,255 adults who had at least one antipsychotic drug record during the pe

SUBMITTER: Kasteridis P 

PROVIDER: S-EPMC6890489 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature