Weight loss and breast cancer incidence in postmenopausal women.

ABSTRACT:

Background

Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women's Health Initiative Observational Study.

Methods

Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self-report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change an

SUBMITTER: Chlebowski RT 

PROVIDER: S-EPMC6890496 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature