Diagnosis of Metal Hypersensitivity in Total Knee Arthroplasty: A Case Report.

ABSTRACT: Delayed type hypersensitivity (DTH) reactions are considered infrequent complications in arthroplasty, but have been recognized to be associated with devastating morbidity and substantial decrease in quality of life of affected patients. Chronic inflammation of artificial joints and associated loss of peri-implant bone often require revision surgery. Methods for the diagnosis of implant-related DTH are available but infrequently considered to the full extent. Sequential diagnostics based on exclusion of septic complications, local and systemic metal level determination, lymphocyte transformation testing (LTT), and local T cell subset analysis are required for an unequivocal DTH diagnosis. Here, we report on a patient with a history of chronic rheumatoid arthritis and an unfavorable outcome

SUBMITTER: Schoon J 

PROVIDER: S-EPMC6890602 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature