Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure.

ABSTRACT:

Aims/hypothesis

Exposure to environmental pollution has been consistently linked to diabetes incidence in humans, but the potential causative mechanisms remain unclear. Given the critical role of regulated insulin secretion in maintaining glucose homeostasis, environmental chemicals that reach the endocrine pancreas and cause beta cell injury are of particular concern. We propose that cytochrome P450 (CYP) enzymes, which are involved in metabolising xenobiotics, could serve as a useful biomarker for direct exposure of islets to pollutants. Moreover, functional CYP enzymes in islets could also impact beta cell physiology. The aim of this study was to determine whether CYP1A enzymes are activated in islets following direct or systemic exposure to environmental pollutants.

Methods<

SUBMITTER: Ibrahim M 

PROVIDER: S-EPMC6890627 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature