An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.

ABSTRACT: How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutua

SUBMITTER: Tekpli X 

PROVIDER: S-EPMC6890706 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature