Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models.

ABSTRACT: Bifidobacteria, the initial colonisers of breastfed infant guts, are considered as the key commensals that promote a healthy gastrointestinal tract. However, little is known about the key metabolic differences between different strains of these bifidobacteria, and consequently, their suitability for their varied commercial applications. In this context, the present study applies a constraint-based modelling approach to differentiate between 36 important bifidobacterial strains, enhancing their genome-scale metabolic models obtained from the AGORA (Assembly of Gut Organisms through Reconstruction and Analysis) resource. By studying various growth and metabolic capabilities in these enhanced genome-scale models across 30 different nutrient environments, we classified the bifidobacteria into

SUBMITTER: Devika NT 

PROVIDER: S-EPMC6890778 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature