Different transmission routes and the risk of advanced HIV disease: A systematic review and network meta-analysis of observational studies.

ABSTRACT:

Background

A substantial proportion of people living with HIV (PLHIV) present for care with advanced HIV disease (AHD), which may result in difficulty reaching the "90-90-90" target to end AIDS in 2030. We assessed the risk of AHD for different transmission routes to summarize the evidence for priority prevention strategies for key populations.

Methods

Observational studies published before September 10th, 2019 in the PubMed, EMBASE, Web of Science and Chinese electronic databases were analysed. The outcomes of interest were the number of PLHIV and AHD patients and their associated transmission routes. We assessed the risk of AHD among the different transmission routes using the multi-armed network meta-analysis based on the Bayesian method. The associations between AHD and

SUBMITTER: Chen Q 

PROVIDER: S-EPMC6890975 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature