Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states - A direct comparison with ¹⁵O-H₂O positron emission tomography using a hybrid PET/MR system.

ABSTRACT: Phase-contrast mapping (PCM) magnetic resonance imaging (MRI) provides easy-access non-invasive quantification of global cerebral blood flow (gCBF) but its accuracy in altered perfusion states is not established. We aimed to compare paired PCM MRI and ¹⁵O-H₂O positron emission tomography (PET) measurements of gCBF in different perfusion states in a single scanning session. Duplicate combined gCBF PCM-MRI and ¹⁵O-H₂O PET measurements were performed in the resting condition, during hyperventilation and after acetazolamide administration (post-ACZ) using a 3T hybrid PET/MR system. A total of 62 paired gCBF measurements were acquired in 14 healthy young male volunteers. Average gCBF in resting state measured by PCM-MRI and ¹⁵O-H₂

SUBMITTER: Puig O 

PROVIDER: S-EPMC6890999 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature